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KMID : 0614620080520030171
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Korean Journal of Gastroenterology
2008 Volume.52 No. 3 p.171 ~ p.178
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Pancreas And Biliary Tract : Pancreatic Endocrine Tumors: Clinical Manifestations and Predictive Factors Associated with Survival
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Paik Woo-Hyun
Park Joo-Kyung
Woo Sang-Myung
Ryu Ji-Kon
Kim Yong-Tae
Yoon Yong-Bum
Lee Sang-Hyub
Yang Ki-Young
Seo Jeong-Kyun
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Abstract
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Background/Aims: Since pancreatic endocrine tumors (PET) are rare and heterogeneous diseases, their survival and prognosis are not well known. Due to recent advances in CT/MRI technology, incidentalomas of the pancreas are detected with increasing frequency. This study presents results of clinical manifestations of PET and predictive factors associated with survival.
Methods: From year 1990 through 2006, medical records of 98 patients (56 men, 42 women) who were diagnosed as PET pathologically at Seoul National University Hospital were reviewed retrospectively.
Results: Ages ranged from 17 to 76 years (mean 51.6±1.3 years) with a mean follow-up of 3.6±0.4 years (range 0-10.1 years). Overall 5-year survival rate was 68.1%, and 5-year survival rate of the patients who had distant metastases at initial diagnosis was 43.9%. Functioning tumors [hazard ratio (HR) 0.229, 95% confidence interval (CI) 0.056-0.943, p=0.041] and lymph node or liver metastases (HR 5.537, 95% CI 2.106-14.555, p＜0.001) were the significant prognostic factors associated with survival rate. However, tumor size and pathology showed no significant association with survival.
Conclusions: Because small and pathologically benign nature do not predict good prognosis in PET, aggressive treatment such as curative resection would be considered initially even in the case of incidental PET.
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KEYWORD
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Pancreatic neoplasm, Islet cell, Survival, Prognosis
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